Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences
نویسندگان
چکیده
منابع مشابه
Bile duct‐ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences
BACKGROUND & AIMS Patients with decompensated cirrhosis are susceptible to infection. Innate immune dysfunction and development of organ failure are considered to underlie this. A rodent model of liver disease sharing these phenotypic features would assist in vivo study of underlying mechanisms and testing of therapeutics. We evaluated three models to identify which demonstrated the greatest cl...
متن کاملStatistical Analysis of Pathobiochemical Signatures in Bile Duct Ligated Mice
Explorative data analysis 3 Data import . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Gene Probes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Data visualization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Actb quality control . . . . . . . ....
متن کاملNeutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice.
Obstruction of the common bile duct in a variety of clinical settings leads to cholestatic liver injury. An important aspect of this injury is hepatic inflammation, with neutrophils as the prominent cell type involved. However, the pathophysiologic role of the infiltrating neutrophils during cholestatic liver injury remains unclear. Therefore, we tested the hypothesis that neutrophils contribut...
متن کاملThe effect of berberine nanomicelles on hepatic cirrhosis in bile duct-ligated rats
Objective (s): The anti-fibrotic effect of chronic berberine (BBR) had demonstrated previously in a rat model of bile duct ligation (BDL). The aim of present study was to investigate hepatoprotective effect of BBR nanomicelles on liver cirrhosis induced by BDL in male rats.Materials and methods: After 21 days of drugs’ treatments, the serum and tissue levels of hepatic markers were measured and...
متن کاملHaemodynamic and renal evolution of the bile duct-ligated rat.
In the present study we have characterized the evolution of changes in systemic haemodynamics (thermodilution in conscious animals) and sodium balance (metabolic cages) in a model of liver cirrhosis induced by chronic bile duct ligation (BDL). Mean arterial pressure (BDL, 111.5+/-4.7 mmHg; sham-operated, 122.9+/-3.0 mmHg) and peripheral vascular resistance (BDL, 2.63+/-0.08 units; sham-operated...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Liver International
سال: 2015
ISSN: 1478-3223
DOI: 10.1111/liv.12876